All Phenotypes Kcna5<tm1(Kcna1)Lndn> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Kcna5^{tm1(Kcna1)Lndn}
targeted mutation 1, Barry London
MGI:2384510

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kcna5^{tm1(Kcna1)Lndn}/Kcna5^{tm1(Kcna1)Lndn}	involves: C57BL/6	MGI:3583141

Allelic Composition	Kcna5^{tm1(Kcna1)Lndn}/Kcna5^{tm1(Kcna1)Lndn}
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcna5^{tm1(Kcna1)Lndn} mutation (0 available); any Kcna5 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal vascular smooth muscle physiology ( J:70694 )

• pulmonary artery smooth muscle cells with lower normoxic current density than controls

decreased vasoconstriction ( J:70694 )

• hypoxic pulmonary vasoconstriction significantly reduced

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:78122 )

• insensitive to 4-aminopyridine indcued changes in cardiac rhythm

muscle

abnormal vascular smooth muscle physiology ( J:70694 )

• pulmonary artery smooth muscle cells with lower normoxic current density than controls

decreased vasoconstriction ( J:70694 )

• hypoxic pulmonary vasoconstriction significantly reduced

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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