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Id2tm1Yyk
Targeted Allele Detail
Summary
Symbol: Id2tm1Yyk
Name: inhibitor of DNA binding 2; targeted mutation 1, Yoshifumi Yokota
MGI ID: MGI:2384134
Synonyms: Id2-, Idb2-
Gene: Id2  Location: Chr12:25143798-25146091 bp, - strand  Genetic Position: Chr12, 8.57 cM, cytoband B
Alliance: Id2tm1Yyk page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:53267
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 2.2 kb region of the gene including the promoter and an exon was replaced with a PGK-neo cassette via homologous recombination. Northern blot analysis using the full cDNA sequence as a probe demonstrated the absence of gene expression in liver from homozygous mutant animals. (J:53267)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 7 assay results
3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 8 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Id2tm1Yyk
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Id2 Mutation:  19 strains or lines available
References
Original:  J:53267 Yokota Y, et al., Development of peripheral lymphoid organs and natural killer cells depends on the helix-loop-helix inhibitor Id2. Nature. 1999 Feb 25;397(6721):702-6
All:  64 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory