Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gckrtm1Bms
Name:	glucokinase regulatory protein; targeted mutation 1, Bristol Myers Squibb
MGI ID:	MGI:2384075
Synonyms:	GKRP -
Gene:	Gckr  Location: Chr5:31454787-31484658 bp, + strand  Genetic Position: Chr5, 17.27 cM
Alliance:	Gckrtm1Bms page

Germline Transmission:	Earliest citation of germline transmission: J:58949
Parent Cell Line:	CJ7 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 1 and 2 were replaced with a neomycin cassette inserted by homologous recombination. Neither transcript nor protein was detected by Northern or Western blot analyses of liver tissue obtained from homozygous mutant mice. (J:58949)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gckr Mutation:	42 strains or lines available

Original:	J:58949 Farrelly D, et al., Mice mutant for glucokinase regulatory protein exhibit decreased liver glucokinase: a sequestration mechanism in metabolic regulation. Proc Natl Acad Sci U S A. 1999 Dec 7;96(25):14511-6
All:	1 reference(s)