Phenotypes associated with this allele

• Allele Symbol: Gckr^tm1Bms
• Allele Name: targeted mutation 1, Bristol Myers Squibb
• Allele ID: MGI:2384075
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gckr^tm1Bms/Gckr^tm1Bms	involves: 129S1/Sv * C57BL/6	MGI:3723311
hm2	Gckr^tm1Bms/Gckr^tm1Bms	involves: 129S1/Sv * ICR	MGI:2445722

Genotype
MGI:3723311

hm1

• Allelic Composition: Gckr^tm1Bms/Gckr^tm1Bms
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal glucose homeostasis ( J:58949 )

• fasting lactate levels are nearly doubled on a 40% sucrose/40% fat diet

increased circulating glucose level ( J:58949 )

• on a 40% sucrose/40% fat diet

• elevated fasting plasma glucose levels that progressively increase with time on the test diet

increased circulating insulin level ( J:58949 )

• 40% sucrose/40% fat diet

• fasting insulin levels are doubled

insulin resistance ( J:58949 )

• 40% sucrose/40% fat diet

Genotype
MGI:2445722

hm2

• Allelic Composition: Gckr^tm1Bms/Gckr^tm1Bms
• Genetic Background: involves: 129S1/Sv * ICR

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:58949 )

N • no effect on plasma insulin either fasting or when fed

abnormal enzyme/coenzyme level ( J:58949 )

• stimulation of mRNA for glucokinase by insulin treatment is delayed relative to control animals but reaches equivalent levels by 8 hrs as compared to 2 hours

• glucokinase levels stimulated by insulin treatment never reach control levels

abnormal glucose homeostasis ( J:58949 )

impaired glucose tolerance ( J:58949 )

• greater increase in blood glucose levels after IP injection of glucose

• no difference in plasma insulin when compared to controls

decreased liver glycogen level ( J:58949 )

• liver glycogen levels are 33% lower than controls when on a normal diet

decreased glucokinase activity ( J:58949 )

• decreased glucokinase activity in the liver (by 15% when fasting and by 48% when fed ad-lib)

liver/biliary system

decreased liver glycogen level ( J:58949 )

• liver glycogen levels are 33% lower than controls when on a normal diet