Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Dnmt3btm2Enl
Name:	DNA methyltransferase 3B; targeted mutation 2, En Li
MGI ID:	MGI:2182410
Gene:	Dnmt3b  Location: Chr2:153491370-153529650 bp, + strand  Genetic Position: Chr2, 75.79 cM, cytoband A2-A3
Alliance:	Dnmt3btm2Enl page

Germline Transmission:	Earliest citation of germline transmission: J:58298
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Targeting took place in J1 ES cells heterozygous for Dnmt3btm1Enl. A 2.4kb region encoding the PC and ENV motifs was replaced with a hygromycin selection cassette via homologous recombination. (J:58298)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Dnmt3b Mutation:	50 strains or lines available

Original:	J:58298 Okano M, et al., DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell. 1999 Oct 29;99(3):247-57
All:	5 reference(s)