Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Liftm1Phb
Name:	leukemia inhibitory factor; targeted mutation 1, Philippe Brulet
MGI ID:	MGI:2181618
Synonyms:	LIF-, LIF(-), LIF KO
Gene:	Lif  Location: Chr11:4207587-4222514 bp, + strand  Genetic Position: Chr11, 2.94 cM, cytoband A1-A2
Alliance:	Liftm1Phb page

Germline Transmission:	Earliest citation of germline transmission: J:77410
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: A 3.3 kb region, encompassing all of the exonic and intronic sequence as well as a portion of the 3' untranslated region, was replaced by a vector containing lacZ. Sequence analysis confirmed the junction of the endogenous promoter with the lacZ start codon. (J:77410)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	7 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lif Mutation:	11 strains or lines available

Original:	J:77410 Escary JL, et al., Leukaemia inhibitory factor is necessary for maintenance of haematopoietic stem cells and thymocyte stimulation. Nature. 1993 May 27;363(6427):361-4
All:	29 reference(s)