Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Celtm1Dyh
Name:	carboxyl ester lipase; targeted mutation 1, David Y Hui
MGI ID:	MGI:2180867
Synonyms:	CEL(-)
Gene:	Cel  Location: Chr2:28445831-28453415 bp, - strand  Genetic Position: Chr2, 19.38 cM
Alliance:	Celtm1Dyh page

Germline Transmission:	Earliest citation of germline transmission: J:32099
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: Exon 4 was disrupted by the insertion of a neomycin resistance gene. The disruption occurred immediately upstream of the active site domains and precludes the processing of exon 11, which is essential for secretion of the protein from the pancreas. Western blot analysis of pancreatic homogenates from homozygous mutant mice showed an absence of protein product, truncated or otherwise. (J:32099)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cel Mutation:	32 strains or lines available

Original:	J:32099 Howles PN, et al., Dietary free and esterified cholesterol absorption in cholesterol esterase (bile salt-stimulated lipase) gene-targeted mice. J Biol Chem. 1996 Mar 22;271(12):7196-202
All:	6 reference(s)