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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Celtm1Dyh
targeted mutation 1, David Y Hui
MGI:2180867
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Celtm1Dyh/Celtm1Dyh involves: 129S1/Sv * 129X1/SvJ * Black Swiss MGI:3722848
hm2
 		Celtm1Dyh/Celtm1Dyh involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3722844
cx3
 		Celtm1Dyh/Celtm1Dyh
Pnliptm1Dyh/Pnliptm1Dyh 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3722845


Genotype
MGI:3722848
hm1
Allelic
Composition		 Celtm1Dyh/Celtm1Dyh
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Celtm1Dyh mutation (0 available); any Cel mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal intestinal lipid absorption ( J:32099 )
• cholesteryl ester absorption is 35% of wild-type levels
• however, absorption of triglycerides and cholesterol is normal

digestive/alimentary system
abnormal intestinal lipid absorption ( J:32099 )
• cholesteryl ester absorption is 35% of wild-type levels
• however, absorption of triglycerides and cholesterol is normal




Genotype
MGI:3722844
hm2
Allelic
Composition		 Celtm1Dyh/Celtm1Dyh
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Celtm1Dyh mutation (0 available); any Cel mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal intestinal lipid absorption ( J:124658 )
• using [14C]cholesteryl oleate, absorption of cholesteryl ester is nearly eliminated
• however, absorption of triglycerides, cholesterol, and retinyl ester is normal

digestive/alimentary system
abnormal intestinal lipid absorption ( J:124658 )
• using [14C]cholesteryl oleate, absorption of cholesteryl ester is nearly eliminated
• however, absorption of triglycerides, cholesterol, and retinyl ester is normal




Genotype
MGI:3722845
cx3
Allelic
Composition		 Celtm1Dyh/Celtm1Dyh
Pnliptm1Dyh/Pnliptm1Dyh
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Celtm1Dyh mutation (0 available); any Cel mutation (32 available)
Pnliptm1Dyh mutation (1 available); any Pnlip mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal intestinal lipid absorption ( J:124658 )
• triglyceride absorption is dramatically reduced (60.1+/- 3.8%) compared to wild-type (91.5 +/- 0.7%) mice and in Pnliptm1Dyh homozygotes (80.1+/- 3.6%) when fed a Western-style diet (high fat)
• using a [14]C]tripalmitin tracer to determine the levels of triglycerides, long chain retinyl esters and cholesterol absorption, mice have 52% less [14]C] than in wild-type mice after 9 hours
• using [3]retinyl palmitate mixed in olive oil or in low fat chow, the rate and amount of retinyl ester absorption is reduced to a greater extent than in Pnliptm1Dyh homozygotes
• using [14C]cholesteryl oleate, absorption of cholesteryl ester is nearly eliminated as in Celtm1Dyh homozygotes
decreased intestinal cholesterol absorption ( J:124658 )
• when fed a high fat diet, cholesterol absorption is decreased similar to in Pnliptm1Dyh homozygotes
decreased susceptibility to diet-induced obesity ( J:124658 )
• mice weight less than wild-type counterparts after 0.5 weeks on a high fat diet
decreased circulating insulin level ( J:124658 )
• when fed a high fat diet, fasting insulin levels are lower than in similarly treated wild-type mice
decreased circulating cholesterol level ( J:124658 )
• when fed a high fat diet, plasma cholesterol levels are 45% less than in wild-type mice fed a high fat diet
insulin resistance ( J:124658 )
• mice are more insulin resistant than wild-type mice and Celtm1Dyh homozygotes

liver/biliary system
decreased liver weight ( J:124658 )
• liver weight gain associated with consuming a high fat diet is reduced compared to in similarly treated wild-type mice

growth/size/body
increased lean body mass ( J:124658 )
• at 25 weeks of age, mice on a high fat diet have 12.3% more lean body mass than wild-type mice
decreased susceptibility to diet-induced obesity ( J:124658 )
• mice weight less than wild-type counterparts after 0.5 weeks on a high fat diet

adipose tissue
decreased percent body fat/body weight ( J:124658 )
• at 25 weeks of age, mice on a high fat diet have 12.5% less body fat mass than wild-type mice

digestive/alimentary system
abnormal intestinal lipid absorption ( J:124658 )
• triglyceride absorption is dramatically reduced (60.1+/- 3.8%) compared to wild-type (91.5 +/- 0.7%) mice and in Pnliptm1Dyh homozygotes (80.1+/- 3.6%) when fed a Western-style diet (high fat)
• using a [14]C]tripalmitin tracer to determine the levels of triglycerides, long chain retinyl esters and cholesterol absorption, mice have 52% less [14]C] than in wild-type mice after 9 hours
• using [3]retinyl palmitate mixed in olive oil or in low fat chow, the rate and amount of retinyl ester absorption is reduced to a greater extent than in Pnliptm1Dyh homozygotes
• using [14C]cholesteryl oleate, absorption of cholesteryl ester is nearly eliminated as in Celtm1Dyh homozygotes
decreased intestinal cholesterol absorption ( J:124658 )
• when fed a high fat diet, cholesterol absorption is decreased similar to in Pnliptm1Dyh homozygotes




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory