Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Aldh1a2tm1Gdu
Name:	aldehyde dehydrogenase family 1, subfamily A2; targeted mutation 1, Gregg Duester
MGI ID:	MGI:2180721
Synonyms:	Raldh2-
Gene:	Aldh1a2  Location: Chr9:71123071-71203525 bp, + strand  Genetic Position: Chr9, 39.85 cM
Alliance:	Aldh1a2tm1Gdu page

Germline Transmission:	Earliest citation of germline transmission: J:75950
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 3 and 4 are deleted and are replaced by a PGK-hygromycin selectable marker. This prevents translation beyond residue 67 and deletes the entire catalytic domain (residues 271-484) including the catalytic cysteine at residue 301. Whole mount immunohistochemistry experiments confirmed that the encoded protein was undetectable in homozygous embryos. (J:75950)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	110 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Aldh1a2 Mutation:	36 strains or lines available

Original:	J:75950 Mic FA, et al., Novel retinoic acid generating activities in the neural tube and heart identified by conditional rescue of Raldh2 null mutant mice. Development. 2002 May;129(9):2271-82
All:	32 reference(s)