Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Cckbrtm1Kpn
Name:	cholecystokinin B receptor; targeted mutation 1, Alan S Kopin
MGI ID:	MGI:2180591
Gene:	Cckbr  Location: Chr7:105075201-105085546 bp, + strand  Genetic Position: Chr7, 55.86 cM
Alliance:	Cckbrtm1Kpn page

Germline Transmission:	Earliest citation of germline transmission: J:49320
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The insertion of a neomycin selection cassette deleted sequence encoding transmembrane domains V through VII, which are essential for structure. Radiolabeled binding experiments of cerbral plasma membranes isolated from homozygous mutant mice confirmed a lack of functional protein. (J:49320)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Cckbr Mutation:	23 strains or lines available

Original:	J:49320 Langhans N, et al., Abnormal gastric histology and decreased acid production in cholecystokinin-B/gastrin receptor-deficient mice. Gastroenterology. 1997 Jan;112(1):280-6
All:	13 reference(s)