Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol:	Itktm1Ljb
Name:	IL2 inducible T cell kinase; targeted mutation 1, Leslie Berg
MGI ID:	MGI:2178928
Synonyms:	Itk-
Gene:	Itk  Location: Chr11:46215977-46280342 bp, - strand  Genetic Position: Chr11, 27.75 cM
Alliance:	Itktm1Ljb page

Germline Transmission:	Earliest citation of germline transmission: J:48231
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The kinase domain of this gene (amino acids 476-543) spanning from the middle of exon 10 to exon 12 was replaced with a PGK-neo cassette via homologous recombination. Protein product was absent in lymph nodes, spleen, and thymus of homozygous mutant animals via Western blot analysis. (J:48231)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Itk Mutation:	48 strains or lines available

Original:	J:48231 Liu KQ, et al., T cell receptor-initiated calcium release is uncoupled from capacitative calcium entry in Itk-deficient T cells. J Exp Med. 1998 May 18;187(10):1721-7
All:	23 reference(s)