Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol: Dmc1Mei11 Name: DNA meiotic recombinase 1; spermatogonial depletion MGI ID: MGI:2177010 Synonyms: sgdp Gene: Dmc1  Location: Chr15:79445698-79489310 bp, - strand  Genetic Position: Chr15, 37.79 cM, cytoband E Alliance: Dmc1Mei11 page

Histopathology of Dmc1Mei11/Dmc+ mouse testes Show the 2 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:60747
Parent Cell Line:	v6.4 (ES Cell)
Strain of Origin:	(C57BL/6J x 129S4/SvJae)F1

Allele Type:    Chemically induced (other) Mutation:    Nucleotide substitutions   Mutation details: This mutation was identified in an EMS mutagenesis screen for recessive infertility. Two consecutive base changes have been identified at positions 968-969 of the gene transcript. These changes result in an Alanine to Proline amino acid change in a putitive DNA binding structure.. Inheritance:    Recessive

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dmc1 Mutation:	16 strains or lines available

Original:	J:60747 Munroe RJ, et al., Mouse mutants from chemically mutagenized embryonic stem cells. Nat Genet. 2000 Mar;24(3):318-21
All:	3 reference(s)