Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Nr2e1frc
Name:	nuclear receptor subfamily 2, group E, member 1; fierce
MGI ID:	MGI:2176490
Gene:	Nr2e1  Location: Chr10:42437959-42459628 bp, - strand  Genetic Position: Chr10, 22.89 cM
Alliance:	Nr2e1frc page

Strain of Origin:

129P2/OlaHsd

Allele Type:    Spontaneous Mutation:    Intragenic deletion   Mutation details: The underlying mutation responsible for the phenotype in the fierce mouse was identified as a deletion in the Nr2e1 gene. The genomic deletion was confirmed by Southern analysis and no transcript was detectable by Northern analysis in homozygous mutant animals. Presence of a human BAC transgene containing the NR2E1 gene rescues the phenotype of mice homozygous for the fierce mutation. J:99431 (J:71869, J:99431)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

16 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Nr2e1 Mutation:	32 strains or lines available

Original:	J:71869 Young KA, et al., Fierce: a new mouse deletion of Nr2e1; violent behaviour and ocular abnormalities are background-dependent. Behav Brain Res. 2002 May 14;132(2):145-58
All:	11 reference(s)