Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Pltptm1Jia
Name:	phospholipid transfer protein; targeted mutation 1, Xian-cheng Jiang
MGI ID:	MGI:2176342
Synonyms:	PLTP-
Gene:	Pltp  Location: Chr2:164681438-164699628 bp, - strand  Genetic Position: Chr2, 85.27 cM
Alliance:	Pltptm1Jia page

Germline Transmission:	Earliest citation of germline transmission: J:53521
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin selection cassette replaced a genomic fragment containing exon 2, which encodes the initiation codon, the signal peptide and the first 16 amino acids of the mature protein. Northern blot and RNase protection analysis on RNA derived from lung of homozygous mice demonstrated that no detectable transcript was produced from this allele. Activity assays on plasma of homozygous mice confirmed that no functional protein was expressed from this allele. (J:53521)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

8 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pltp Mutation:	30 strains or lines available

Original:	J:53521 Jiang XC, et al., Targeted mutation of plasma phospholipid transfer protein gene markedly reduces high-density lipoprotein levels. J Clin Invest. 1999 Mar;103(6):907-14
All:	37 reference(s)