Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Bak1tm1Thsn
Name:	BCL2-antagonist/killer 1; targeted mutation 1, Craig B Thompson
MGI ID:	MGI:2159364
Synonyms:	bak-
Gene:	Bak1  Location: Chr17:27238786-27247601 bp, - strand  Genetic Position: Chr17, 13.65 cM, cytoband B
Alliance:	Bak1tm1Thsn page

Germline Transmission:	Earliest citation of germline transmission: J:66872
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette replaced a genomic fragment containing exons 2-6. These exons encode the Bcl-2 homology domains of the encoded protein. Western blot analysis on spleen and thymus lysates derived from homozygous mice confirmed that no detectable protein is expressed from this allele. (J:66872)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

28 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Bak1 Mutation:	23 strains or lines available

Original:	J:66872 Lindsten T, et al., The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues. Mol Cell. 2000 Dec;6(6):1389-99
All:	167 reference(s)