Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ptprdtm1Yiw
Name:	protein tyrosine phosphatase receptor type D; targeted mutation 1, Yoichiro Iwakura
MGI ID:	MGI:2158795
Synonyms:	PTPdelta, Ptprd-, RPTDdelta
Gene:	Ptprd  Location: Chr4:75859475-78130198 bp, - strand  Genetic Position: Chr4, 36.94 cM
Alliance:	Ptprdtm1Yiw page

Germline Transmission:	Earliest citation of germline transmission: J:63046
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A PGK-neomycin resistance cassette replaced sequences encoding the first phosphatase signature motif. Northern blot and RT-PCR analyses did not detect mRNA containing the first PTP domain, but did detect a shorter mRNA in brain and kidney from homozygous mutant mice. (J:63046)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	58 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ptprd Mutation:	120 strains or lines available

Original:	J:63046 Uetani N, et al., Impaired learning with enhanced hippocampal long-term potentiation in PTPdelta-deficient mice. EMBO J. 2000 Jun 15;19(12):2775-85
All:	16 reference(s)