Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol: Lmx1btm1Rjo Name: LIM homeobox transcription factor 1 beta; targeted mutation 1, Randy L Johnson MGI ID: MGI:2158463 Synonyms: Lmx1b-, Lmxbneo Gene: Lmx1b  Location: Chr2:33450977-33530620 bp, - strand  Genetic Position: Chr2, 22.48 cM Alliance: Lmx1btm1Rjo page

Retarded development of the glomerular capillaries in Lmx1btm1Rjo/Lmx1btm1Rjo mice Show the 6 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:47316
Parent Cell Line:	AB1 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A PGK-neomycin resistance cassette replaced about 5 kb of sequence including exons 3-7, which encode the second LIM domain, the homeodomain, and most of the carboxy-terminal region. RT-PCR analysis did not detect transcript from the region encoding the homeodomain in homozygous mutant 10 dpc embryos. (J:47316)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	91 assay results 4 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	37 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lmx1b Mutation:	16 strains or lines available

Original:	J:47316 Chen H, et al., Limb and kidney defects in Lmx1b mutant mice suggest an involvement of LMX1B in human nail patella syndrome. Nat Genet. 1998 May;19(1):51-5
All:	39 reference(s)