Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Arrb1tm1Jse
Name:	arrestin, beta 1; targeted mutation 1, J G Seidman
MGI ID:	MGI:2157962
Synonyms:	Arrb1-
Gene:	Arrb1  Location: Chr7:99184673-99255978 bp, + strand  Genetic Position: Chr7, 54.09 cM
Alliance:	Arrb1tm1Jse page

Germline Transmission:	Earliest citation of germline transmission: J:44953
Parent Cell Line:	C1 (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: The gene was disrupted by the insertion of a neomycin resistance cassette and vector sequences through homologous recombination. The insertion results in a defined duplication of a large region of sequence within the gene. The neo cassette is located between the redundant segments, disrupting expression. Northern analysis of total heart and kidney RNA demonstrated that no detectable transcript was present in homozygous mice. Western analysis from crude cytosolic brain preparations failed to detect protein in homozygous mice. (J:44953)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	15 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Arrb1 Mutation:	27 strains or lines available

Original:	J:44953 Conner DA, et al., beta-Arrestin1 knockout mice appear normal but demonstrate altered cardiac responses to beta-adrenergic stimulation. Circ Res. 1997 Dec;81(6):1021-6
All:	57 reference(s)