Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Il1btm1Yiw
Name:	interleukin 1 beta; targeted mutation 1, Yoichiro Iwakura
MGI ID:	MGI:2157396
Synonyms:	Il-1b-, IL-1beta-, Il-1beta KO
Gene:	Il1b  Location: Chr2:129206490-129213059 bp, - strand  Genetic Position: Chr2, 62.97 cM, cytoband F
Alliance:	Il1btm1Yiw page

Germline Transmission:	Earliest citation of germline transmission: J:47429
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: A lacZ-PGK-neomycin resistance cassette replaced part of exon 3, all of exon 4, and part of exon 5, including sequences encoding the amino terminus of the mature protein. Northern blot analysis of activated peritoneal macrophages did not detect transcript in homozygous mutant mice. (J:47429, J:92002)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Il1b Mutation:	24 strains or lines available

Original:	J:47429 Horai R, et al., Production of mice deficient in genes for interleukin (IL)-1alpha, IL-1beta, IL-1alpha/beta, and IL-1 receptor antagonist shows that IL-1beta is crucial in turpentine-induced fever development and glucocorticoid secretion. J Exp Med. 1998 May 4;187(9):1463-75
All:	192 reference(s)