Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Apptm2Cwe
Name:	amyloid beta precursor protein; targeted mutation 2, Charles Weissmann
MGI ID:	MGI:2154535
Synonyms:	APP_, beta APP 0
Gene:	App  Location: Chr16:84751236-84972187 bp, - strand  Genetic Position: Chr16, 46.92 cM, cytoband C3-qter
Alliance:	Apptm2Cwe page

Germline Transmission:	Earliest citation of germline transmission: J:36648
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion     Cre-mediated recombination resulted in the deletion of 200kb of the gene, from exon 2 - 17. (J:36648)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	6 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any App Mutation:	89 strains or lines available

Original:	J:36648 Li ZW, et al., Generation of mice with a 200-kb amyloid precursor protein gene deletion by Cre recombinase-mediated site-specific recombination in embryonic stem cells [published erratum appears in Proc Natl Acad Sci U S A 1996 Oct 15;93(21):12052]. Proc Natl Acad Sci U S A. 1996 Jun 11;93(12):6158-62
All:	27 reference(s)