Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Sox8tm1Weg
Name:	SRY (sex determining region Y)-box 8; targeted mutation 1, Michael Wegner
MGI ID:	MGI:2154329
Synonyms:	Sox8lacZ
Gene:	Sox8  Location: Chr17:25784865-25789666 bp, - strand  Genetic Position: Chr17, 12.69 cM
Alliance:	Sox8tm1Weg page

Germline Transmission:	Earliest citation of germline transmission: J:71578
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: In-frame insertion of a LacZ-neomycin resistance cassette replaced the complete open reading frame and both introns of the gene. RT-PCR and in situ hybridization studies indicate that expression of the LacZ marker replaced endogenous gene expression in homozygous mutant embryos and adult male mice. (J:71578)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	284 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sox8 Mutation:	26 strains or lines available

Original:	J:71578 Sock E, et al., Idiopathic weight reduction in mice deficient in the high-mobility-group transcription factor sox8. Mol Cell Biol. 2001 Oct;21(20):6951-9
All:	24 reference(s)