Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Neurl1atm1Led
Name:	neuralized E3 ubiquitin protein ligase 1A; targeted mutation 1, Philip Leder
MGI ID:	MGI:2153143
Gene:	Neurl1a  Location: Chr19:47167259-47247880 bp, + strand  Genetic Position: Chr19, 39.39 cM
Alliance:	Neurl1atm1Led page

Germline Transmission:	Earliest citation of germline transmission: J:72105
Parent Cell Line:	TC1/TC-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout, Reporter) Mutation:    Insertion   Mutation details: Insertion of an IRES-GFP-PGK-neomycin resistance cassette into the exon encoding the NHR-2 region of the protein disrupted the gene and introduced transcriptional termination sequences downstream of the GFP coding sequences. Northern analyses of brain and skeletal muscle of homozygous mutant mice detected only aberrant transcripts using a 5' probe, and did not detect transcript using a 3' probe. (J:72105)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Neurl1a Mutation:	19 strains or lines available

Original:	J:72105 Vollrath B, et al., Isolation of a Murine Homologue of the Drosophila neuralized Gene, a Gene Required for Axonemal Integrity in Spermatozoa and Terminal Maturation of the Mammary Gland. Mol Cell Biol. 2001 Nov;21(21):7481-94
All:	1 reference(s)