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Wnt1tm1Mrc
Targeted Allele Detail
Summary
Symbol: Wnt1tm1Mrc
Name: wingless-type MMTV integration site family, member 1; targeted mutation 1, Mario Capecchi
MGI ID: MGI:2153126
Synonyms: int-1-
Gene: Wnt1  Location: Chr15:98687738-98691711 bp, + strand  Genetic Position: Chr15, 54.65 cM, cytoband F1-F3
Alliance: Wnt1tm1Mrc page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:67737
Parent Cell Line:  CC1.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsTandem insertion of multiple copies of a neomycin resistance cassette into exon 2 by homologous recombination disrupted the gene. (J:67737)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Wnt1 Mutation:  30 strains or lines available
References
Original:  J:67737 Thomas KR, et al., Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development. Nature. 1990 Aug 30;346(6287):847-50
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory