Phenotypes associated with this allele

• Allele Symbol: Wnt1^tm1Mrc
• Allele Name: targeted mutation 1, Mario Capecchi
• Allele ID: MGI:2153126
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Wnt1^tm1Mrc/Wnt1^tm1Mrc	involves: 129S7/SvEvBrd * C57BL/6	MGI:3639497

Genotype
MGI:3639497

hm1

• Allelic Composition: Wnt1^tm1Mrc/Wnt1^tm1Mrc
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, incomplete penetrance ( J:67737 )

• one of six homozygotes (from two litters) examined at E17.5 died in utero

neonatal lethality, incomplete penetrance ( J:67737 )

• six of ten homozygotes (from 5 litters) died within 0.5 days of birth; three survived 0.5 days but died before day 1.5 and one female survived to adulthood

nervous system

hydrocephaly ( J:67737 )

• by E17.5, all homozygous mutant embryos displayed a mild midbrain hydrocephaly

• single female surviving to adulthood displayed hydrocephaly in the caudal region of the cerebral hemispheres as well as in the midbrain

abnormal midbrain morphology ( J:67737 )

• at E14.5, homozygous mutant embryos exhibited a highly malformed mesencephalon

• at E17.5, a large portion of mesencephalic tissue was absent

abnormal frontal lobe morphology ( J:67737 )

• at E17.5, the mutant frontal lobes appeared to extend more caudally, probably due to expansion into regions normally occupied by the missing mesencephalon

abnormal metencephalon morphology ( J:67737 )

• at E14.5, homozygous mutant embryos exhibited a highly malformed metencephalon

absent cerebellum ( J:67737 )

• at E17.5, the mutant cerebellar region was absent

• surprisingly, the single female survivor was hydrocephalic but retained the posterior portion of the cerebellum

behavior/neurological

abnormal motor coordination/balance ( J:67737 )

• single female survivor pivoted both clockwise and counterclockwise around the rear legs but was able to jump >30 cm verically, indicating absence of muscle wastage or defects in local motor neuron activity

• in addition, this female responded normally to stimuli of light, smell, touch and sound

ataxia ( J:67737 )

• single female surviving to adulthood exhibited severe ataxia