Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Scaptm1Mbjg
Name:	SREBF chaperone; targeted mutation 1, Joseph L Goldstein
MGI ID:	MGI:2148743
Synonyms:	Scap-, SCAPflox, Scaptm1Gsn
Gene:	Scap  Location: Chr9:110162356-110214017 bp, + strand  Genetic Position: Chr9, 59.91 cM
Alliance:	Scaptm1Mbjg page

Germline Transmission:	Earliest citation of germline transmission: J:69592
Parent Cell Line:	SM1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A a loxP-flanked neomycin resistance cassette located 3 kb upstream of exon 1. An additional loxP site was inserted in intron 1. (J:69592)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	12 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Scap Mutation:	60 strains or lines available

Original:	J:69592 Matsuda M, et al., SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation. Genes Dev. 2001 May 15;15(10):1206-16
All:	38 reference(s)