Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gja8tm1Scr
Name:	gap junction protein, alpha 8; targeted mutation 1, The Scripps Institute
MGI ID:	MGI:2137525
Synonyms:	alpha8(-), Gja8m1
Gene:	Gja8  Location: Chr3:96820882-96833336 bp, - strand
Alliance:	Gja8tm1Scr page

Germline Transmission:	Earliest citation of germline transmission: J:73651
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout, Reporter) Mutation:    Insertion   Mutation details: A lacZ gene, followed by a neomycin selection cassette, was inserted in-frame after the sixth codon. Western blot analysis demonstrated that no GJA8 protein is detectable in lens homogenates derived from homozygous mice. Beta-galactosidase is expressed from this allele under the control of the endogenous promoter. (J:73651)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gja8 Mutation:	33 strains or lines available

Original:	J:73651 Rong P, et al., Disruption of Gja8 (alpha8 connexin) in mice leads to microphthalmia associated with retardation of lens growth and lens fiber maturation. Development. 2002 Jan;129(1):167-74
All:	9 reference(s)