Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Aplp2tm1Dbo Name: amyloid beta precursor-like protein 2; targeted mutation 1, David R Borchelt MGI ID: MGI:2137246 Synonyms: APLP2- Gene: Aplp2  Location: Chr9:31060853-31123111 bp, - strand  Genetic Position: Chr9, 16.66 cM, cytoband A2-B Alliance: Aplp2tm1Dbo page

Neuromuscular synapse defects in Apptm3.1Zhe/Apptm3.1Zhe Aplp2tm1Dbo/Aplp2tm1Dbo mice Show the 1 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:45851
Parent Cell Line:	AB2.1 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1b-m2

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Replacement of the promoter region and first exon with a neomycin cassette. Western blot analysis on samples derived from nervous tissue and other peripheral tissues of homozygous mutant mice failed to detect any protein. (J:45851)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

26 assay results 3 RNA-Seq or microarray experiment(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Aplp2 Mutation:	30 strains or lines available

Original:	J:45851 von Koch CS, et al., Generation of APLP2 KO mice and early postnatal lethality in APLP2/APP double KO mice. Neurobiol Aging. 1997 Nov-Dec;18(6):661-9
All:	47 reference(s)