Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Penk-rstm1Pig
Name:	preproenkephalin, related sequence; targeted mutation 1, Pain Investigation Group
MGI ID:	MGI:2136456
Synonyms:	enk-, Penk2tm1Zim, Penk KO, PPNK-
Gene:	Penk-rs  Location: unknown  Genetic Position: Chr9, Syntenic
Alliance:	Penk-rstm1Pig page

Germline Transmission:	Earliest citation of germline transmission: J:35826
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A PGK-neomycin resistance cassette replaced 54 bp of the 5' part of exon 3 and parts of the second intron. The mutated allele contains a rearrangement downstream from the insertion site with a partial duplication of exon 3 sequences. Northern blot analysis of brain and testis detected nearly no encoded mRNA in homozygous mice. (J:35826)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Penk-rs Mutation:	3 strains or lines available

Original:	J:35826 Konig M, et al., Pain responses, anxiety and aggression in mice deficient in pre-proenkephalin. Nature. 1996 Oct 10;383(6600):535-8
All:	27 reference(s)