Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tac1tm1Bbm
Name:	tachykinin 1; targeted mutation 1, Allan Basbaum
MGI ID:	MGI:2136170
Synonyms:	PPT-A-, PPTA-, SPP-
Gene:	Tac1  Location: Chr6:7555061-7562978 bp, + strand  Genetic Position: Chr6, 3.31 cM
Alliance:	Tac1tm1Bbm page

Germline Transmission:	Earliest citation of germline transmission: J:67563
Parent Cell Line:	CB1-4 (ES Cell)
Strain of Origin:	C57BL/6J x (Rb(11.16)2H x Rb(16.17)32Lub)F1

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Insertion of a PGK-neomycin resistance cassette into the gene replaced a coding region in exon 3 and deleted a coding region in exon 6. Immunoreactivity was not detected in the lumbar spinal cord of homozygous mutant mice. (J:67563)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tac1 Mutation:	36 strains or lines available

Original:	J:67563 Cao YQ, et al., Primary afferent tachykinins are required to experience moderate to intense pain. Nature. 1998 Mar 26;392(6674):390-4
All:	56 reference(s)