Phenotypes associated with this allele

• Allele Symbol: Tac1^tm1Bbm
• Allele Name: targeted mutation 1, Allan Basbaum
• Allele ID: MGI:2136170
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tac1^tm1Bbm/Tac1^tm1Bbm	involves: C57BL/6J	MGI:3624705

Genotype
MGI:3624705

hm1

• Allelic Composition: Tac1^tm1Bbm/Tac1^tm1Bbm
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

abnormal urinary bladder physiology ( J:107963 )

• with treatment of mice with an NK2 agonist prior to a 2-hour saline infusion, 84% of mutant mice displayed areflexic bladders compared to 28% of controls

urinary incontinence ( J:107963 )

• with treatment of mice with an NK2 agonist prior to a 2-hour saline infusion, 84% of mutant mice displayed overflow incontinence compared to 28% of controls

behavior/neurological

abnormal pain threshold ( J:127006 )

• F2rl1(PAR2)-agonist-induced hyperalgesia is not observed in mutants as is seen in wild-type mice