Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Lama5tm1Jhm Name: laminin, alpha 5; targeted mutation 1, Jeffrey H Miner MGI ID: MGI:1934917 Synonyms: Lama5 - Gene: Lama5  Location: Chr2:179818166-179867652 bp, - strand  Genetic Position: Chr2, 102.7 cM Alliance: Lama5tm1Jhm page

Syndactyly in Lama5tm1Jhm/Lama5tm1Jhm embryos Show the 4 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:51557
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: An in-frame lacZ gene followed by a neomycin cassette replaced sequences encoding the N-terminal domains VI and V. Immunohistochemical analysis did not detect protein in distal limb basal lamina from homozygous mutant mice. (J:51557)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	46 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	27 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lama5 Mutation:	153 strains or lines available

Original:	J:51557 Miner JH, et al., Roles for laminin in embryogenesis: exencephaly, syndactyly, and placentopathy in mice lacking the laminin alpha5 chain. J Cell Biol. 1998 Dec 14;143(6):1713-23
All:	26 reference(s)