Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Erbb2tm1Cbm
Name:	erb-b2 receptor tyrosine kinase 2; targeted mutation 1, Carmen Birchmeier
MGI ID:	MGI:1929071
Synonyms:	erbB2-
Gene:	Erbb2  Location: Chr11:98303310-98328542 bp, + strand  Genetic Position: Chr11, 61.75 cM, cytoband D
Alliance:	Erbb2tm1Cbm page

Germline Transmission:	Earliest citation of germline transmission: J:48515
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout, Reporter) Mutation:    Insertion   Mutation details: Fusion of lacZ sequences to an exon encoding the cytoplasmic juxtamembrane domain. This allele expresses a fusion protein of ErbB2 and beta-galactosidase that lacks the kinase domain of ErbB2. (J:48515)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

8 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Erbb2 Mutation:	59 strains or lines available

Original:	J:48515 Britsch S, et al., The ErbB2 and ErbB3 receptors and their ligand, neuregulin-1, are essential for development of the sympathetic nervous system. Genes Dev. 1998 Jun 15;12(12):1825-36
All:	10 reference(s)