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Itgb1tm1Ref
Targeted Allele Detail
Summary
Symbol: Itgb1tm1Ref
Name: integrin beta 1 (fibronectin receptor beta); targeted mutation 1, Reinhard Fassler
MGI ID: MGI:1926498
Synonyms: beta1fl, beta1 integrin (fl), floxed beta1 integrin
Gene: Itgb1  Location: Chr8:129412135-129459681 bp, + strand  Genetic Position: Chr8, 76.09 cM, cytoband E2
Alliance: Itgb1tm1Ref page
Hair and skin phenotypes of various keratinocyte conditional Itgb1 alleles

Show the 5 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:78985
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change, Reporter)
Mutation:    Insertion
 
Mutation detailsExons 2 through 7 were flanked by single loxP sites in intron 1 and intron 8. The construct included a promoterless LacZ reporter gene introduced after the downstream loxP site, enabling the detection of cre mediated recombination by lacZ expression. Northern blot analysis demonstrated that expression of the floxed allele was unaffected by the presence of the loxP sites. (J:78985)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 309 assay results
In Structures Affected by this Mutation: 25 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Itgb1 Mutation:  59 strains or lines available
References
Original:  J:78985 Potocnik AJ, et al., Fetal and adult hematopoietic stem cells require beta1 integrin function for colonizing fetal liver, spleen, and bone marrow. Immunity. 2000 Jun;12(6):653-63
All:  69 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory