Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Ppardtm1Jps
Name:	peroxisome proliferator activator receptor delta; targeted mutation 1, Jeffrey M Peters
MGI ID:	MGI:1889516
Synonyms:	PPARbeta-, Pparbeta/delta-null
Gene:	Ppard  Location: Chr17:28451715-28520446 bp, + strand  Genetic Position: Chr17, 14.64 cM
Alliance:	Ppardtm1Jps page

Germline Transmission:	Earliest citation of germline transmission: J:63040
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129/Sv

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: The last exon of this gene was disrupted by insertion of a neomycin resistance cassette via homologous recombination. Mutant transcript was detected in adipose, brain, and skin tissue from homozygous mutant animals by Northern blot analysis, but protein product was not detect in hepatic nuclear extract by Western blot analysis. (J:63040)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

7 anatomical structure(s)

List all tumor models in MMHCdb carrying Ppardtm1Jps

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ppard Mutation:	68 strains or lines available

Original:	J:63040 Peters JM, et al., Growth, adipose, brain, and skin alterations resulting from targeted disruption of the mouse peroxisome proliferator-activated receptor beta(delta). Mol Cell Biol. 2000 Jul;20(14):5119-28
All:	36 reference(s)