Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Timp2tm1Jjc
Name:	tissue inhibitor of metalloproteinase 2; targeted mutation 1, John J Caterina
MGI ID:	MGI:1888709
Synonyms:	Timp-2-
Gene:	Timp2  Location: Chr11:118191887-118246237 bp, - strand  Genetic Position: Chr11, 83.09 cM
Alliance:	Timp2tm1Jjc page

Germline Transmission:	Earliest citation of germline transmission: J:64002
Parent Cell Line:	HM-1 (ES Cell)
Strain of Origin:	129P2/OlaHsd-Hprt1b-m3

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion     Replacement of exons 2 and 3 with a neomycin cassette. (J:64002)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Timp2 Mutation:	20 strains or lines available

Original:	J:64002 Caterina JJ, et al., Inactivating mutation of the mouse tissue inhibitor of metalloproteinases-2(Timp-2) gene alters proMMP-2 activation. J Biol Chem. 2000 Aug 25;275(34):26416-22
All:	3 reference(s)