Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Vpreb1atm1Ilm
Name:	V-set pre-B cell surrogate light chain 1A; targeted mutation 1, Inga-Lill Martensson
MGI ID:	MGI:1859923
Synonyms:	VpreB1 -
Gene:	Vpreb1a  Location: Chr16:16686265-16687119 bp, - strand  Genetic Position: Chr16, 10.46 cM
Alliance:	Vpreb1atm1Ilm page

Germline Transmission:	Earliest citation of germline transmission: J:53512
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: All of exon 1 and a portion of exon 2 were replaced with a neomycin selection cassette. RT-PCR analysis confirmed that while Vpreb1 transcript was absent in homozygous mutant mice, normal levels of Vpreb2 were present. (J:53512)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Vpreb1a Mutation:	24 strains or lines available

Original:	J:53512 Martensson A, et al., Partial block in B lymphocyte development at the transition into the pre-B cell receptor stage in Vpre-B1-deficient mice. Int Immunol. 1999 Mar;11(3):453-60
All:	4 reference(s)