Oas1b<Flv-r> Spontaneous Allele Detail MGI Mouse (MGI:1857800)

Oas1b^Flv-r
Spontaneous Allele Detail

Summary

Symbol:	Oas1b^Flv-r
Name:	2'-5' oligoadenylate synthetase 1B; flavivirus resistance
MGI ID:	MGI:1857800
Synonyms:	Flv^r
Gene:	Oas1b Location: Chr5:120950700-120962228 bp, + strand Genetic Position: Chr5, 60.64 cM, cytoband F
Alliance:	Oas1b^Flv-r page

Mutation
origin

Strain of Origin:

various

Mutation
description

Allele Type:		Spontaneous
Mutation:		Single point mutation
		Mutation details: This allele confers resistance to flavivirus infection. Susceptible mouse strains produce a protein lacking 30% of the C-terminal region due a nucleotide substitution. The T-to-C transition in resistant strains results in the change of a premature stop codon to an arginine codon at position 253 (p.253R). (J:77001*)
Inheritance:		Dominant

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available Cell Lines: 0 lines available
Carrying any Oas1b Mutation:	15 strains or lines available

Notes

The majority of mouse strains carry the susceptibility allele. Only the Det, BSVR, BRVR, CASA/RK, CAST/Ei, and PRI carry the resistance allele. The MOLD/Rk strain carried the allele for minor resistance.

Genbank ID for this allele: AF481734

References

Original:	J:15009 Sabin AB, Nature of inherited resistance to viruses affecting the nervous system. Proc Natl Acad Sci U S A. 1952 Jun;38(6):540-46
All:	14 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23