Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol:	Notch2tm1Yha
Name:	notch 2; targeted mutation 1, Yoshio Hamaha
MGI ID:	MGI:1857783
Synonyms:	N2LacZ, Notch2m
Gene:	Notch2  Location: Chr3:97920854-98057683 bp, + strand  Genetic Position: Chr3, 42.42 cM
Alliance:	Notch2tm1Yha page

Germline Transmission:	Earliest citation of germline transmission: J:55841
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: An in-frame lacZ-neomycin resistance cassette replaced the exons encoding the second through the sixth ankyrin repeats. This allele expresses a beta galactosidase fusion protein. (J:55841)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	48 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Notch2 Mutation:	97 strains or lines available

Original:	J:55841 Hamada Y, et al., Mutation in ankyrin repeats of the mouse Notch2 gene induces early embryonic lethality. Development. 1999 Aug;126(15):3415-24
All:	9 reference(s)