Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Tcrbtm1Mom
Name:	T cell receptor beta chain; targeted mutation 1, Peter Mombaerts
MGI ID:	MGI:1857256
Synonyms:	beta-, CBeta-, TCRb-, TCRbeta-, TCR-Cbeta-
Gene:	Tcrb  Location: Chr6:40868230-41535305 bp, + strand  Genetic Position: Chr6, cytoband A-C

Germline Transmission:	Earliest citation of germline transmission: J:22591
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: 15kb of sequence was replaced with a PGK-neo cassette. The deletion included one of the two D gene segments, ten of the twelve J gene segments, and both constant gene segments. (J:22591)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

List all tumor models in MMHCdb carrying Tcrbtm1Mom

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 12 strains available      Cell Lines: 0 lines available
Carrying any Tcrb Mutation:	94 strains or lines available

Original:	J:22591 Mombaerts P, et al., Creation of a large genomic deletion at the T-cell antigen receptor beta-subunit locus in mouse embryonic stem cells by gene targeting. Proc Natl Acad Sci U S A. 1991 Apr 15;88(8):3084-7
All:	489 reference(s)