Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Spntm1Bam
Name:	sialophorin; targeted mutation 1, Blair Ardman
MGI ID:	MGI:1857246
Synonyms:	CD43-
Gene:	Spn  Location: Chr7:126731404-126736995 bp, - strand  Genetic Position: Chr7, 69.35 cM, cytoband F3-F4
Alliance:	Spntm1Bam page

Germline Transmission:	Earliest citation of germline transmission: J:29272
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A 300 nucleotide fragment encoding a portion of the extracellular domain and all of the transmembrane domain was deleted by via homologous recombination strategies. FACS analysis of splenocytes isolated from homozygous mutant mice showed a lack of the encoded protein on the cell surface. (J:29272)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Spn Mutation:	24 strains or lines available

Original:	J:29272 Manjunath N, et al., Negative regulation of T-cell adhesion and activation by CD43. Nature. 1995 Oct 12;377(6549):535-8
All:	44 reference(s)