Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Apoa1tm1Unc
Name:	apolipoprotein A-I; targeted mutation 1, University of North Carolina
MGI ID:	MGI:1857127
Synonyms:	A1-, Apo A1-, Apo A-1 KO, apoa1tm1unc, ApoA-I-
Gene:	Apoa1  Location: Chr9:46139928-46141767 bp, + strand  Genetic Position: Chr9, 25.36 cM, cytoband A2-A4
Alliance:	Apoa1tm1Unc page

Germline Transmission:	Earliest citation of germline transmission: J:2109
Parent Cell Line:	E14TG2a (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A genomic fragment containing exon 2 was replaced by a neomycin resistance cassette. The protein was not detectable in plasma by Ouchterlony double-immunodiffusion tests in homozygous mice. (J:2109)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

List all tumor models in MMHCdb carrying Apoa1tm1Unc

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Apoa1 Mutation:	16 strains or lines available

Original:	J:2109 Williamson R, et al., Marked reduction of high density lipoprotein cholesterol in mice genetically modified to lack apolipoprotein A-I. Proc Natl Acad Sci U S A. 1992 Aug 1;89(15):7134-8
All:	85 reference(s)