Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol:	Agttm2Unc
Name:	angiotensinogen; targeted mutation 2, University of North Carolina
MGI ID:	MGI:1857122
Synonyms:	AgtTgH(Agtdup)1Unc, Tg(Agtdup)1Unc, TgH(Agtdup)1Unc
Gene:	Agt  Location: Chr8:125283326-125296445 bp, - strand  Genetic Position: Chr8, 72.81 cM
Alliance:	Agttm2Unc page

Germline Transmission:	Earliest citation of germline transmission: J:18272
Parent Cell Line:	E14TG2a (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Not Applicable) Mutation:    Duplication   Agttm2Unc involves 1 genes/genome features (Agt) View all   Mutation details: A tandem duplication of the gene was created by "gap-repair" gene targeting. Radioimmunoassay tests demonstrated increased plasma levels of the encoded protein in heterozygous mice. (J:18272)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Agt Mutation:	33 strains or lines available

Original:	J:18272 Smithies O, et al., Targeted gene duplication and disruption for analyzing quantitative genetic traits in mice. Proc Natl Acad Sci U S A. 1994 Apr 26;91(9):3612-5
All:	7 reference(s)