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Ay
Spontaneous Allele Detail
Summary
Symbol: Ay
Name: nonagouti; agouti yellow
MGI ID: MGI:1856798
Synonyms: Ay, A(y)
Gene: a  Location: Chr2:154792519-154892932 bp, + strand  Genetic Position: Chr2, 76.83 cM
Alliance: Ay page
Ay/a mouse

Show the 4 phenotype image(s) involving this allele.

Mutation
origin
Strain of Origin:  old mutant of the mouse fancy
Mutation
description
Allele Type:    Spontaneous
Mutation:    Other
 
Mutation detailsThe Ay mutation appears to be a DNA structural alteration that disrupts a gene, hnRNP associated with lethal yellow (Raly), 5' to the agouti locus and places the agouti locus under the control of the Raly promotor. A report of recombination between Ay and the a and ax alleles suggests that Ay was a pseudoallele of the a locus on the proximal side. However, cloning of the agouti locus and molecular analysis of a showed that the coding region of the three alleles is identical. (J:8877, J:12911, J:17512, J:18921)
Inheritance:    Semidominant
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 8 assay results
1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 15 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Ay
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 12 strains available      Cell Lines: 0 lines available
Carrying any a Mutation:  463 strains or lines available
References
Original:  J:12954 Dunn LC, et al., Studies on Spotting Patterns III. Interaction between Genes Affecting White Spotting and Those Affecting Color in the House Mouse. Genetics. 1937 Mar;22(2):307-18
All:  194 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory