Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Abl1m1
Name:	c-abl oncogene 1, non-receptor tyrosine kinase; mutation 1
MGI ID:	MGI:1856663
Synonyms:	ablm1
Gene:	Abl1  Location: Chr2:31578388-31694239 bp, + strand  Genetic Position: Chr2, 21.86 cM, cytoband B
Alliance:	Abl1m1 page

Germline Transmission:	Earliest citation of germline transmission: J:72519
Parent Cell Line:	CCE/EK.CCE (ES Cell)
Strain of Origin:	129S/SvEv-Gpi1c

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A promoterless neomycin resistance gene was inserted into coding sequences corresponding to the carboxy terminus of the protein, downstream of the tyrosine kinase domain and nuclear targeting sequences. This allele expresses a protein with a functional kinase domain but a disrupted carboxy terminus containing the DNA and actin binding domains. (J:72518)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

8 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Abl1 Mutation:	92 strains or lines available

Original:	J:72519 Schwartzberg PL, et al., Germ-line transmission of a c-abl mutation produced by targeted gene disruption in ES cells. Science. 1989 Nov 10;246(4931):799-803
All:	10 reference(s)