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Gene Expression Data
Assay Details
Assay
Reference: J:38384 Arkell R, et al., BMP-7 influences pattern and growth of the developing hindbrain of mouse embryos. Development. 1997 Jan;124(1):1-12
Assay type: RNA in situ
MGI Accession ID: MGI:1332536
Gene symbol: Bmp7
Gene name: bone morphogenetic protein 7
Probe: Bmp7 cDNA2
Probe preparation: RNA
Results
Specimen 1A: embryonic day 6.5 (more )
Note: Early streak.
Structure Level Pattern Image Note
TS9: primitive streak Present Regionally restricted 1A BMP-7 transcripts are detected at the anterior end of the primitive streak.

Specimen 1B: embryonic day 7.0 (more )
Note: Late streak.
Structure Level Pattern Image Note
TS10: embryo mesoderm Present Regionally restricted 1B BMP-7 mRNA is localized to the rostral third of the primitive streak, the node and to the axial mesoderm emanating from the node.
TS10: node Present Regionally restricted 1B BMP-7 mRNA is localized to the rostral third of the primitive streak, the node and to the axial mesoderm emanating from the node.
TS10: primitive streak Present Regionally restricted 1B BMP-7 mRNA is localized to the rostral third of the primitive streak, the node and to the axial mesoderm emanating from the node.

Specimen 1C: embryonic day 7.0 (more )
Note: Early allantoic bud stage.
Structure Level Pattern Image Note
TS10: primitive streak Weak 1C
TS10: embryo mesoderm Present Regionally restricted 1C BMP-7 transcripts are now detected in the lateral mesoderm of the distal two thirds of the embryonic region.
TS10: node Strong 1C The highest transcript levels are seen in the node and notochord.
TS10: allantois Present 1C

Specimen 1D: embryonic day 7.5 (more )
Note: Early headfold.
Structure Level Pattern Image Note
TS11: primitive streak Present Regionally restricted 1D Expression is absent from the primitive streak, although it is still present in the node.
TS11: allantois Present 1D
TS11: node Present 1D
TS11: notochordal plate Present 1D
TS11: embryo mesoderm Present Regionally restricted 1D Transcripts are seen in the paraxial and lateral mesoderm.

Specimen 1E: embryonic day 7.5 (more )
Note: Headfold, presomite stage.
Structure Level Pattern Image Note
TS11: allantois Present 1E
TS11: node Present 1E
TS11: notochordal plate Present 1E
TS11: embryo mesoderm Present Regionally restricted 1E Expression can be seen in the cranial paraxial mesoderm and heart mesoderm.
TS11: heart Present Regionally restricted 1E Expression can be seen in the cranial paraxial mesoderm and heart mesoderm.

Specimen 1F: embryonic day 7.0 (more )
Note: Allantoic bud stage.
Structure Level Pattern Image Note
TS10: embryo mesoderm Present Regionally restricted 1F Transcripts can be seen in both the lateral and axial mesoderm.

Specimen 1G: embryonic day 7.5 (more )
Note: Headfold, presomite stage embryo.
Structure Level Pattern Image Note
TS11: embryo mesoderm Present 1G
TS11: neural ectoderm Present Regionally restricted 1G BMP-7 transcripts are seen in the ventral neurectoderm, but not in the dorsal neurectoderm.
TS11: surface ectoderm Strong Regionally restricted 1G Transcripts accumulate in the surface ectoderm of the anterior and posterior regions of the embryo.

Specimen 1H: embryonic day 9.0 (more )
Note: 14-somite embryo.
Structure Level Pattern Image Note
TS14: head mesenchyme Present Regionally restricted 1H A section through the forebrain and hindbrain shows BMP-7 transcripts present in the most rostral axial mesoderm.
TS14: neural tube roof plate Present 1H

Specimen not shown: embryonic day 8.0 (more )
Note: 6-somite embryo.
Structure Level Pattern Image Note
TS12: embryo mesenchyme Present Regionally restricted BMP-7 is only detected in sections up to 105 um behind the rostral extent of the axial mesoderm. Transcripts are no longer seen in the mesoderm adjacent to the hindbrain region.

Specimen not shown: embryonic day 8.5 (more )
Note: 12-somite embryo.
Structure Level Pattern Image Note
TS13: embryo mesenchyme Present Regionally restricted BMP-7 expression is only detected in sections up to 140 um behind the rostral extent of the axial mesoderm.

Specimen 1I: embryonic day 8.0 (more )
Note: 6-somite embryo.
Structure Level Pattern Image Note
TS12: neural ectoderm Present Regionally restricted 1I The ventral expression of BMP-7 is most obvious in neurectoderm extending from the anterior of the midbrain to the preotic sulcus and is present up to the preotic sulcus.
TS12: optic sulcus neural ectoderm Present Regionally restricted 1I The ventral expression of BMP-7 is most obvious in neurectoderm extending from the anterior of the midbrain to the preotic sulcus and is present up to the preotic sulcus.
TS12: future spinal cord neural plate Present Regionally restricted 1I Transcripts are found in the midline of the neural plate in two regions: a region of higher signal extends from the anterior limit of the midbrain to the preotic sulcus; a lower level of signal extends from the preotic sulcus to the otic sulcus.

Specimen 1J: embryonic day 8.5 (more )
Note: 10-somite embryo.
Structure Level Pattern Image Note
TS13: future midbrain Present 1J The ventral neurectoderm expression is now essentially confined to the midbrain.

Specimen 1K: embryonic day 9.0 (more )
Note: 16-somite embryo.
Structure Level Pattern Image Note
TS14: embryo ectoderm Present Regionally restricted 1K The ventral neurectoderm of the midbrain and rostral diencephalon contains BMP-7 transcripts as does the dorsal-most neurectoderm in the anterior cranial region.
TS14: future diencephalon Present Regionally restricted 1K The ventral neurectoderm of the midbrain and rostral diencephalon contains BMP-7 transcripts as does the dorsal-most neurectoderm in the anterior cranial region.
TS14: future midbrain Present Regionally restricted 1K The ventral neurectoderm of the midbrain and rostral diencephalon contains BMP-7 transcripts as does the dorsal-most neurectoderm in the anterior cranial region.

Specimen not shown: embryonic day 9.0 (more )
Note: 18-somite embryo.
Structure Level Pattern Image Note
TS14: future midbrain Present Regionally restricted By the 18-somite stage, the diencephalic expression disappears and ventral transcription is again seen only in the midbrain.
TS14: future diencephalon Absent By the 18-somite stage, the diencephalic expression disappears and ventral transcription is again seen only in the midbrain.


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/30/2025
MGI 6.24
The Jackson Laboratory