Sequence Detail

ID/Version

Q9Z0J7 Q6NX63 (UniProt | EBI)

Last sequence update: 2012-10-03
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Growth/differentiation factor 15 {ECO:0000305}; Short=GDF-15 {ECO:0000305};AltName: Full=Macrophage inhibitory cytokine 1 {ECO:0000305}; Short=MIC-1 {ECO:0000303|PubMed:23468844, ECO:0000303|PubMed:28081177};Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 303 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Gdf15	growth differentiation factor 15	50	103	2	23

Sequence references in MGI

J:61788 Hsiao EC, et al., Characterization of growth-differentiation factor 15, a transforming growth factor beta superfamily member induced following liver injury. Mol Cell Biol. 2000 May;20(10):3742-51
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:197174 Tsai VW, et al., TGF-b superfamily cytokine MIC-1/GDF15 is a physiological appetite and body weight regulator. PLoS One. 2013;8(2):e55174
J:246122 Low JK, et al., First Behavioural Characterisation of a Knockout Mouse Model for the Transforming Growth Factor (TGF)-beta Superfamily Cytokine, MIC-1/GDF15. PLoS One. 2017;12(1):e0168416
J:251850 Emmerson PJ, et al., The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL. Nat Med. 2017 Oct;23(10):1215-1219
J:251855 Mullican SE, et al., GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates. Nat Med. 2017 Oct;23(10):1150-1157
J:251981 Yang L, et al., GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand. Nat Med. 2017 Oct;23(10):1158-1166
J:254140 Hsu JY, et al., Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15. Nature. 2017 Oct 12;550(7675):255-259
J:261053 Wang T, et al., GDF15 is a heart-derived hormone that regulates body growth. EMBO Mol Med. 2017 Aug;9(8):1150-1164
J:283184 Xiong Y, et al., Long-acting MIC-1/GDF15 molecules to treat obesity: Evidence from mice to monkeys. Sci Transl Med. 2017 Oct 18;9(412)