Sequence Detail

ID/Version

Q9QZW0 Q3KQR4 (UniProt | EBI)

Last sequence update: 2007-01-09
Last annotation update: 2024-01-24

Sequence description from provider

RecName: Full=Phospholipid-transporting ATPase 11C; EC=7.6.2.1 {ECO:0000269|PubMed:21423173, ECO:0000269|PubMed:24898253, ECO:0000269|PubMed:24904167, ECO:0000269|PubMed:26799398, ECO:0000269|PubMed:30018401};AltName: Full=ATPase class VI type 11C

Provider

SWISS-PROT

Sequence

Polypeptide 1129 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Atp11c	ATPase, class VI, type 11C	22	98	3	12

Sequence references in MGI

J:59384 Halleck MS, et al., Differential expression of putative transbilayer amphipath transporters. Physiol Genomics. 1999 Nov 11;1(3):139-50
J:171924 Yabas M, et al., ATP11C is critical for the internalization of phosphatidylserine and differentiation of B lymphocytes. Nat Immunol. 2011 May;12(5):441-9
J:171925 Siggs OM, et al., The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrow. Nat Immunol. 2011 May;12(5):434-40
J:172799 Siggs OM, et al., X-linked cholestasis in mouse due to mutations of the P4-ATPase ATP11C. Proc Natl Acad Sci U S A. 2011 May 10;108(19):7890-5
J:211626 Segawa K, et al., Caspase-mediated cleavage of phospholipid flippase for apoptotic phosphatidylserine exposure. Science. 2014 Jun 6;344(6188):1164-8
J:216008 Yabas M, et al., Mice deficient in the putative phospholipid flippase ATP11C exhibit altered erythrocyte shape, anemia, and reduced erythrocyte life span. J Biol Chem. 2014 Jul 11;289(28):19531-7
J:248831 Yabas M, et al., ATP11C Facilitates Phospholipid Translocation across the Plasma Membrane of All Leukocytes. PLoS One. 2016;11(1):e0146774
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89