Sequence Detail

ID/Version

Q9QY30 A2AUN4 Q9QZE8 (UniProt | EBI)

Last sequence update: 2011-06-28
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Bile salt export pump {ECO:0000303|Ref.4}; EC=7.6.2.- {ECO:0000269|PubMed:23764895};AltName: Full=ATP-binding cassette sub-family B member 11;AltName: Full=Sister of P-glycoprotein {ECO:0000250|UniProtKB:O70127};

Provider

SWISS-PROT

Sequence

Polypeptide 1321 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Abcb11	ATP-binding cassette, sub-family B member 11	121	100	4	13

Sequence references in MGI

J:59591 Green RM, et al., Molecular cloning and characterization of the murine bile salt export pump. Gene. 2000 Jan 4;241(1):117-23
J:67548 Wang R, et al., Targeted inactivation of sister of P-glycoprotein gene (spgp) in mice results in nonprogressive but persistent intrahepatic cholestasis. Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):2011-6
J:94496 Figge A, et al., Hepatic overexpression of murine Abcb11 increases hepatobiliary lipid secretion and reduces hepatic steatosis. J Biol Chem. 2004 Jan 23;279(4):2790-9
J:149062 Paulusma CC, et al., Activity of the bile salt export pump (ABCB11) is critically dependent on canalicular membrane cholesterol content. J Biol Chem. 2009 Apr 10;284(15):9947-54
J:188866 Zhang Y, et al., Abcb11 deficiency induces cholestasis coupled to impaired beta-fatty acid oxidation in mice. J Biol Chem. 2012 Jul 13;287(29):24784-94
J:205077 Wang R, et al., Defective canalicular transport and toxicity of dietary ursodeoxycholic acid in the abcb11-/- mouse: transport and gene expression studies. Am J Physiol Gastrointest Liver Physiol. 2013 Aug 15;305(4):G286-94
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89