Sequence Detail

ID/Version

Q9JJY3 Q3UTQ5 (UniProt | EBI)

Last sequence update: 2000-10-01
Last annotation update: 2026-06-10

Sequence description from provider

RecName: Full=Sphingomyelin phosphodiesterase 3 {ECO:0000305}; EC=3.1.4.12 {ECO:0000269|PubMed:12566438, ECO:0000269|PubMed:15051724};AltName: Full=Neutral sphingomyelinase 2; Short=nSMase-2; Short=nSMase2 {ECO:0000303|PubMed:21550

Provider

SWISS-PROT

Sequence

Polypeptide 655 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Smpd3	sphingomyelin phosphodiesterase 3, neutral	102	109	3	13

Sequence references in MGI

J:62281 Hofmann K, et al., Cloning and characterization of the mammalian brain-specific, Mg2+-dependent neutral sphingomyelinase. Proc Natl Acad Sci U S A. 2000 May 23;97(11):5895-900
J:97284 Stoffel W, et al., Neutral sphingomyelinase 2 (smpd3) in the control of postnatal growth and development. Proc Natl Acad Sci U S A. 2005 Mar 22;102(12):4554-9
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:100158 Aubin I, et al., A deletion in the gene encoding sphingomyelin phosphodiesterase 3 (Smpd3) results in osteogenesis and dentinogenesis imperfecta in the mouse. Nat Genet. 2005 Aug;37(8):803-5
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:292528 Wu BX, et al., Identification of novel anionic phospholipid binding domains in neutral sphingomyelinase 2 with selective binding preference. J Biol Chem. 2011 Jun 24;286(25):22362-71
J:383892 Tani M, et al., Neutral sphingomyelinase 2 is palmitoylated on multiple cysteine residues. Role of palmitoylation in subcellular localization. J Biol Chem. 2007 Mar 30;282(13):10047-10056
J:384363 Marchesini N, et al., Biochemical properties of mammalian neutral sphingomyelinase 2 and its role in sphingolipid metabolism. J Biol Chem. 2003 Apr 18;278(16):13775-83
J:384416 Marchesini N, et al., Role for mammalian neutral sphingomyelinase 2 in confluence-induced growth arrest of MCF7 cells. J Biol Chem. 2004 Jun 11;279(24):25101-11