Sequence Detail

ID/Version

Q9JJS0 (UniProt | EBI)

Last sequence update: 2000-10-01
Last annotation update: 2026-06-10

Sequence description from provider

RecName: Full=Signal peptide, CUB and EGF-like domain-containing protein 2 {ECO:0000305};AltName: Full=Protein CEGP1 {ECO:0000303|PubMed:11528127};AltName: Full=Scube/You {ECO:0000303|PubMed:22677548};Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 997 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Scube2	signal peptide, CUB domain, EGF-like 2	26	103	3	8

Sequence references in MGI

J:69388 Grimmond S, et al., Expression of a novel mammalian epidermal growth factor-related gene during mouse neural development. Mech Dev. 2001 Apr;102(1-2):209-11
J:71644 Amid C, et al., Comparative genomic sequencing reveals a strikingly similar architecture of a conserved syntenic region on human chromosome 11p15.3 (including gene ST5) and mouse chromosome 7. Cytogenet Cell Genet. 2001;93(3-4):284-90
J:262647 Lin YC, et al., Endothelial SCUBE2 Interacts With VEGFR2 and Regulates VEGF-Induced Angiogenesis. Arterioscler Thromb Vasc Biol. 2017 Jan;37(1):144-155
J:382884 Wierbowski BM, et al., Hedgehog Pathway Activation Requires Coreceptor-Catalyzed, Lipid-Dependent Relay of the Sonic Hedgehog Ligand. Dev Cell. 2020 Nov 23;55(4):450-467.e8
J:383046 Creanga A, et al., Scube/You activity mediates release of dually lipid-modified Hedgehog signal in soluble form. Genes Dev. 2012 Jun 15;26(12):1312-25
J:383049 Tukachinsky H, et al., Dispatched and scube mediate the efficient secretion of the cholesterol-modified hedgehog ligand. Cell Rep. 2012 Aug 30;2(2):308-20